Eye, Hair And Skin Color Can Be Predicted From DNA Of Anonymous Person

A new tool to accurately predict eye, hair and skin color from human biological material — even a small DNA sample, has beeen developed by an international team, led by scientists from the School of Science at IUPUI and Erasmus MC University Medical Center Rotterdam in the Netherlands.

This all-in-one pigmentation profile tool provides a physical description of the person in a way that has not previously been possible by generating all three pigment traits together using a freely available webtool.

An international team, led by scientists from the School of Science at IUPUI and Erasmus MC University Medical Center Rotterdam, has developed a novel tool to accurately predict eye, hair and skin color from human biological material. The innovative high-probability and high-accuracy complete pigmentation profile webtool is available online without charge. Credit: Walsh lab in School of Science at IUPUI

The tool is designed to be used when standard forensic DNA profiling is not helpful because no reference DNA exists against which to compare the evidence sample.

The HIrisPlex-S DNA test system is capable of simultaneously predicting eye, hair and skin color phenotypes from DNA. Users, such as law enforcement officials or anthropologists, can enter relevant data using a laboratory DNA analysis tool, and the webtool will predict the pigment profile of the DNA donor.

“We have previously provided law enforcement and anthropologists with DNA tools for eye color and for combined eye and hair color, but skin color has been more difficult,” said forensic geneticist Susan Walsh from IUPUI, who co-directed the study.

“Importantly, we are directly predicting actual skin color divided into five subtypes — very pale, pale, intermediate, dark and dark to black — using DNA markers from the genes that determine an individual’s skin coloration. This is not the same as identifying genetic ancestry. You might say it’s more similar to specifying a paint color in a hardware store rather than denoting race or ethnicity.

“If anyone asks an eyewitness what they saw, the majority of time they mention hair color and skin color. What we are doing is using genetics to take an objective look at what they saw,” Walsh said.

The innovative high-probability and high-accuracy complete pigmentation profile webtool is available online without charge.

“With our new HIrisPlex-S system, for the first time, forensic geneticists and genetic anthropologists are able to simultaneously generate eye, hair and skin color information from a DNA sample, including DNA of the low quality and quantity often found in forensic casework and anthropological studies,” said Manfred Kayser of Erasmus MC, co-leader of the study.

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